TFK Co., Ltd.

TFK Co., Ltd. (ティーエフケイ株式会社) is a Japanese health-food company based in Hyogo-ku, Kobe, Hyogo Prefecture. It markets dietary supplements built around a proprietary photosynthetic bacterium strain it calls RAP99, and it presents itself as a microbial-enzyme (微生物酵素) specialist that has pursued microorganism research for close to half a century. Its corporate site describes the company's mission as protecting health through the power of photosynthetic bacteria, framed as "life and nature's purification." The company's product line is centered on RAP99, a strain name derived from the initials of Rhodobacter ("R"), Azotoformans ("A") and the code BP0899 ("P" and "99"). TFK states that RAP99 contains LPS (lipopolysaccharide), a substance found in microorganisms in soil and plants, and that its RAP99-derived LPS was recognized as having a new structure and received a substance patent in 2020. Products are manufactured in the company's own domestic factory, and several items are described as made in GMP-certified plants and free of food additives or preservatives. Flagship products include TFK (テイエフケー), formerly known as Toda Fronti Enzyme (戸田フロンティ酵素), a 30 mg tablet said to be 100% RAP99; Touda Kouso (トーダ酵素), described as the most popular item in the RAP99 series and formulated with lactic acid bacteria and yeast; Sanjyu (三寿), a 3 mm micro-tablet combining RAP99-derived LPS with spore-forming lactic acid bacteria; Hyakka-dama (百花玉), which adds glucomannan, bifidobacteria and lactic acid bacteria; Kensuke-dama (健助玉), a BCAA (valine, leucine, isoleucine at a 1:2:1 ratio) supplement with lactic acid bacteria and RAP99; and Kansuke-dama (関助玉), a food with function claims containing non-denatured type II collagen positioned for knee joint flexibility and mobility. TFK sells mainly direct to consumers in Japan through telephone, fax and internet orders, offering subscription (定期便) and bulk (おまとめ便) purchase options with discounts. The company also runs customer testimonials and media coverage sections on its site, and it has begun developing brand characters, including "Raprapu" (らぷらぷ) for RAP99. Its stated address is Wadayama-dori 1-chome 2-25-D407, Hyogo-ku, Kobe, Hyogo Prefecture.

TFK Co., Ltd. is a Japanese company based in Hyogo-ku, Kobe, Hyogo Prefecture, where it operates as a health-food manufacturer and direct seller. Public information about its corporate history is limited, but its own materials describe a long-running focus on microorganisms: the company states that it has pursued microorganism research for close to half a century, and that the RAP99 strain was selected from that body of work. The strain name RAP99 was constructed from the initial "R" of Rhodobacter, the "A" of Azotoformans, and the code BP0899 ("P" and "99"). A central development in the company's recent history is its work on LPS (lipopolysaccharide) derived from RAP99. TFK states that RAP99-LPS was recognized as having a new structure and that a substance patent was obtained in 2020. This patented ingredient became the platform for the company's supplement range, which is marketed under the banner of "microbial enzymes" (微生物酵素) and "photosynthetic bacteria." The company's product pages describe manufacturing in its own domestic factory, with several products made in GMP-certified plants and formulated without food additives or preservatives. The product line has expanded over time. TFK (テイエフケー), formerly called Toda Fronti Enzyme (戸田フロンティ酵素), is a 30 mg tablet described as 100% RAP99. Touda Kouso (トーダ酵素) combines RAP99 with lactic acid bacteria and yeast and is described as the most popular item in the RAP99 series. Sanjyu (三寿) is a 3 mm micro-tablet that pairs RAP99-derived LPS with spore-forming lactic acid bacteria. Hyakka-dama (百花玉) adds glucomannan, bifidobacteria and lactic acid bacteria. Kensuke-dama (健助玉) is a BCAA supplement (valine, leucine and isoleucine in a 1:2:1 ratio) with lactic acid bacteria and RAP99. Kansuke-dama (関助玉) is a food with function claims containing non-denatured type II collagen, positioned to support knee joint flexibility and mobility. In 2026 the company continued to promote the brand through awards, exhibitions and character development. Its site reported that Sanjyu won two awards at the Lacalpa Awards 2026, that it exhibited at the 26th Annual Meeting of the Japan Anti-Aging Medical Society, and that an official RAP99 character named "Raprapu" (らぷらぷ) was created. TFK sells primarily direct to consumers in Japan via telephone, fax and the internet, offering subscription and bulk-purchase discounts, and maintains customer testimonial and media coverage sections on its website.

• Substance patent obtained for RAP99-derived LPS.

• Product pages for TFK, Touda Kouso, Sanjyu and Hyakka-dama dated on the official site.

• Kansuke-dama product page dated on the official site.

• Kensuke-dama product page dated on the official site.

• Exhibited at the 26th Annual Meeting of the Japan Anti-Aging Medical Society.

• Sanjyu won two awards at the Lacalpa Awards 2026.

• Official RAP99 character "Raprapu" announced.

Microbial-enzyme health supplements built on the proprietary photosynthetic bacterium RAP99, sold direct to consumers in Japan.

• TFK (テイエフケー)

  Formerly Toda Fronti Enzyme; a 30 mg tablet described as 100% RAP99, additive-free, containing RAP99-derived LPS.

• Touda Kouso (トーダ酵素)

  RAP99 processed with lactic acid bacteria and yeast; described as the most popular item in the RAP99 series, encapsulated in plant-derived capsules and made in a GMP-certified plant.

• Sanjyu (三寿)

  A 3 mm micro-tablet combining RAP99-derived LPS with spore-forming lactic acid bacteria; no preservatives or food additives.

• Hyakka-dama (百花玉)

  Combines RAP99 with water-soluble dietary fiber glucomannan, bifidobacteria and lactic acid bacteria; made in a GMP-certified plant.

• Kensuke-dama (健助玉)

  A supplement with three essential amino acids (leucine, valine, isoleucine) in a 1:2:1 ratio, plus lactic acid bacteria and RAP99.

• Kansuke-dama (関助玉)

  A food with function claims containing non-denatured type II collagen, positioned to support knee joint flexibility and mobility.

1. 1微生物酵素 | ティーエフケイ株式会社のコーポレートサイトです。tfk-corp.co.jp
2. 2商品紹介 | 微生物酵素 | 光合成細菌 | RAP99 | ティーエフケイtfk-corp.co.jp
3. 3TFK | テイエフケー | 旧 戸田フロンティ酵素tfk-corp.co.jp
4. 4三寿 | さんじゅ | 微生物酵素 | 光合成細菌 | RAP99tfk-corp.co.jp
5. 5TFK Co., Ltd. (Japan) - Wikidatawikidata.org