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Spyre Therapeutics

Spyre Therapeutics is a clinical-stage biotechnology company developing next-generation immunology therapies.

Last updated September 16, 2026

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Overview

Spyre Therapeutics is a clinical-stage biotechnology company based in Waltham, United States. According to its website, it is committed to developing next-generation therapies that elevate the standard in immunology by delivering more complete disease control, greater durability, and a simpler treatment experience for patients. Its pipeline of novel antibodies and combinations targets validated mechanisms with the potential to treat immune-mediated diseases, including programs SPY001 (α4β7), SPY002 (TL1A), SPY003 (IL-23), SPY120 (α4β7 + TL1A), and SPY130 (α4β7 + IL-23).

History

Spyre Therapeutics is a clinical-stage biotechnology company based in Waltham, United States. Its website states that it is committed to developing next-generation therapies that elevate the standard in immunology by delivering more complete disease control, greater durability, and a simpler treatment experience for patients. The company describes a pipeline of novel antibodies and combinations targeting validated mechanisms with the potential to treat immune-mediated diseases, listing programs SPY001 (α4β7), SPY002 (TL1A), SPY003 (IL-23), SPY120 (α4β7 + TL1A), and SPY130 (α4β7 + IL-23). It also states that its team has deep experience developing and commercializing treatments across a broad range of diseases. On December 10, 2024, the company announced grants of inducement awards.

Products and positioning

Clinical-stage biotechnology company committed to developing next-generation therapies that elevate the standard in immunology.

  • SPY001

  • SPY002

  • SPY003

  • SPY120

  • SPY130

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