SiriusXT Ltd

SiriusXT Ltd is an Irish deep-technology company based in Dublin that develops and sells soft X-ray microscopy instruments for the life sciences. It was formed in 2015 as a spin-out from the Spectroscopy Group in the School of Physics at University College Dublin (UCD), starting from a team of three co-founders and growing into a multidisciplinary group of physicists, engineers, scientists and entrepreneurs. The company's founding premise was to take soft X-ray tomography — a technique historically confined to large synchrotron facilities — and make it available as a laboratory-scale instrument that individual research labs could own and operate. The centrepiece of the company's offering is the SXT-100, which SiriusXT describes as the world's first commercial, laboratory-based soft X-ray microscope. The instrument produces high-resolution, label-free 3D images of whole, intact cells at nanometer-scale resolution, allowing researchers to visualise organelle structure and distribution in a near-native state without the chemical labelling or sectioning that many conventional imaging methods require. SiriusXT positions the SXT-100 as a tool for disease research, drug research and nanomedicine, where it can be used to observe cellular changes during infection, cancer or neurodegeneration, to validate nanomedicine delivery, and to evaluate therapeutic effects and toxicity. Beyond the instrument itself, SiriusXT promotes correlative workflows that integrate soft X-ray tomography with CLEM (correlative light and electron microscopy) and volumeEM approaches. The company markets these as "CLEXM" workflows, arguing that combining soft X-ray tomography with light and electron microscopy provides multi-scale, context-rich imaging, improves throughput, reduces data storage burdens, and helps identify rare events and untagged structures that might otherwise be missed. SiriusXT operates in the specialised scientific-instrumentation segment of the life-sciences tools market. Its customers are research laboratories, core imaging facilities and pharmaceutical or biomedical research groups, and the company has worked with international early-adopter partners. It maintains ongoing collaboration with the UCD School of Physics, the Conway Institute of Biomolecular and Biomedical Research, and the wider synchrotron-based soft X-ray microscopy community. The company presents its technology as making cutting-edge cellular imaging accessible, affordable and efficient, and as a means of accelerating progress in disease research and drug discovery. Its website is published in both English and Simplified Chinese, reflecting an ambition to serve international research markets.

SiriusXT was formed in 2015 as a spin-out from the Spectroscopy Group in the School of Physics at University College Dublin (UCD). The founding team consisted of three co-founders, and the company's stated purpose was to make high-resolution cellular imaging accessible to research laboratories by developing a laboratory-scale soft X-ray microscope. Soft X-ray tomography had previously been associated mainly with synchrotron light sources — large, shared national facilities — so the ambition to build a compact, lab-based instrument represented a significant technical and commercial undertaking. From that initial team of three, SiriusXT grew a multidisciplinary staff of physicists, engineers, scientists and entrepreneurs. The company developed the SXT-100, which it describes as the world's first commercial, laboratory-based soft X-ray microscope. The instrument is designed to image whole, intact cells in 3D at nanometer-scale resolution in a label-free, near-native state, addressing applications in disease research, drug research and nanomedicine. SiriusXT has collaborated with the UCD School of Physics and the Conway Institute of Biomolecular and Biomedical Research, and it maintains ties with the synchrotron-based soft X-ray microscopy community. The company has also worked with international early-adopter partners who have taken up the SXT-100, and it promotes correlative workflows — marketed as CLEXM — that combine soft X-ray tomography with CLEM and volumeEM imaging to provide multi-scale context. The company is based in Dublin, Ireland, and its website is published in English and Simplified Chinese, indicating an orientation toward international research markets. SiriusXT presents its technology as a disruptive and innovative solution for whole-cell imaging intended to accelerate progress in disease research and drug discovery.

• 2015

  SiriusXT is formed as a spin-out from the Spectroscopy Group in the School of Physics, University College Dublin, with three co-founders.

• SiriusXT develops and commercialises the SXT-100, described as the world's first commercial, laboratory-based soft X-ray microscope.

• The company grows from three co-founders into a multidisciplinary team of physicists, engineers, scientists and entrepreneurs.

• SiriusXT collaborates with the UCD School of Physics, the Conway Institute of Biomolecular and Biomedical Research, and international early-adopter partners.

Developer and vendor of the world's first commercial, laboratory-scale soft X-ray microscope, positioned as making high-resolution, label-free 3D whole-cell imaging accessible, affordable and efficient for research labs.

• SXT-100

  A commercial, laboratory-scale soft X-ray microscope for high-resolution, label-free 3D imaging of whole, intact cells at nanometer-scale resolution.

• CLEXM correlative workflows

  Workflows integrating soft X-ray tomography with CLEM and volumeEM for multi-scale, context-rich imaging.

1. 1Soft X-ray Microscopy for Advanced Cellular Imaging | SiriusXTsiriusxt.com
2. 2About SiriusXT | Pioneers in Soft X-ray Imaging Technologysiriusxt.com
3. 3SiriusXT Ltd (Ireland) — Wikidatawikidata.org