Sentieon

Sentieon® develops and supplies accelerated bioinformatics secondary analysis tools that process genomics data with high computing efficiency and exceptional accuracy. Incorporated in July 2014, the company develops highly optimized algorithms for bioinformatics applications, drawing on expertise in algorithm, software, and system optimization. Its sequencer-agnostic secondary analysis software provides CPU (x86 & ARM)-accelerated drop-in replacements or improvements for tools such as BWA-MEM, STAR, Minimap2, GATK, and Mutect2, and supports large cohort joint calling. The company states its software runs on any Intel, AMD, or ARM server and is deployable locally or online.

Sentieon® was incorporated in July 2014 and develops highly optimized algorithms for bioinformatics applications, using the team's expertise in algorithm, software, and system optimization. The company describes itself as a team of professionals experienced in image processing, telecom, computational lithography, large-scale data mining, and bioinformatics, and states that it strives to enable precision data for precision medicine. Its tools have received recognition in multiple challenges, including first place in all categories (SNV, INDEL, and SV precision) in the ICGC-TCGA Dream Mutation Calling Challenge (Tumor/Normal), top overall performance and highest reproducibility in the precisionFDA Consistency Challenge (Germline), and highest INDEL precision and highest SNP recall in the precisionFDA Truth Challenge (Germline).

Enabling Precision Data for Precision Medicine; accelerated, sequencer-agnostic, software-only bioinformatics secondary analysis with high computing efficiency and exceptional accuracy.

• DNAscope

  Sentieon DNAscope provides improved accuracy due to improved active region detection, more powerful local assembly of reads, and incorporation of pre-trained machine learning models for both short reads and long reads sequencers.

• DNAseq and TNseq

  Sentieon® DNAseq® and TNseq® software tools for NGS data processing are BWA/GATK drop-in replacements, recognized with a Bio-IT Innovative Practices Award.

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