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Prilosec OTC

Prilosec OTC is an over-the-counter omeprazole delayed-release tablet acid reducer for frequent heartburn.

Last updated September 10, 2026

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Overview

Prilosec OTC is an over-the-counter heartburn medicine whose active ingredient is omeprazole delayed-release tablet 20 mg (equivalent to 20.6 mg omeprazole magnesium), an acid reducer. According to its official product page, one pill taken in the morning blocks heartburn all day and all night, and it works by preventing excess acid production. It is available in 14, 28 and 42 count sizes, and the official site describes it as the #1 Doctor recommended brand in the Proton Pump Inhibitors category.

Products and positioning

Over-the-counter frequent heartburn relief; #1 Doctor recommended brand in the Proton Pump Inhibitors category.

  • Prilosec OTC, Omeprazole Delayed Release Tablets, Acid Reducer, Treats Frequent Heartburn for 24 Hour Relief

    Active ingredient omeprazole delayed-release tablet 20 mg (equivalent to 20.6 mg omeprazole magnesium), an acid reducer that provides long-lasting heartburn relief. Available in 14, 28 and 42 count sizes.

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