leadXpro

leadXpro is a Swiss Contract Research Organization (CRO) founded in 2015 and headquartered in Villigen, Switzerland. The company focuses on enabling structure-based drug discovery on membrane proteins, a class of drug targets that are scientifically important yet notoriously difficult to work with. Its stated mission is to unlock tomorrow's medicines together, better and faster, by combining protein science, biophysics and structural biology into an integrated service platform for pharmaceutical and biotechnology clients. leadXpro's core expertise lies in membrane protein production, structural biology and hit discovery. The company offers gene-to-protein services, construct engineering and optimization, off-the-shelf proteins, and functional testing, alongside advanced biophysical characterization of membrane proteins. Its technology toolkit includes cryo-electron microscopy (CryoEM), time-resolved X-ray crystallography, and ultra-large virtual screening, as well as biophysical methods such as Grating-Coupled Interferometry (GCI), MST/TRIC, mass spectrometry, differential scanning fluorimetry (DSF, nanoDSF, CPM), FSEC-TS, dynamic and static light scattering (DLS, SLS), and analytical SEC. These capabilities support clients from early-stage discovery through lead optimization. According to its own reporting, leadXpro has over ten years of experience in structure-based drug discovery and has collaborated on more than 150 projects covering 120 different membrane proteins with leading biotech and pharmaceutical companies. The company describes itself as delivering Swiss quality and has published in top-tier scientific journals, advancing membrane protein research. It positions itself as a collaborative, flexible partner offering free feasibility assessments to prospective clients. leadXpro operates as a private company and is not publicly listed. Its headquarters in Villigen places it within Switzerland's life-science ecosystem. The company serves a global client base of biotech and pharmaceutical researchers who need high-quality membrane protein reagents, structural data and biophysical insights to advance drug discovery programs.

leadXpro was founded in 2015 in Switzerland as a Contract Research Organization dedicated to membrane protein science and structure-based drug discovery. From its base in Villigen, the company built a platform that combines protein production, biophysical characterization and structural biology to serve pharmaceutical and biotechnology clients. Over its first decade, leadXpro reports having worked on more than 150 projects spanning 120 different membrane proteins, collaborating with leading biotech and pharmaceutical companies. This track record reflects the company's focus on difficult targets that are central to many therapeutic areas but hard to produce and study. The company has also published in top-tier scientific journals, contributing to the broader field of membrane protein research. leadXpro's service portfolio has grown to cover the full arc from gene to protein, including construct engineering, expression, purification, functional testing, and off-the-shelf proteins. On the structural side, it employs cryo-electron microscopy and time-resolved X-ray crystallography, while its biophysics offering includes Grating-Coupled Interferometry, MST/TRIC, mass spectrometry, thermal shift assays and light scattering techniques. It also provides ultra-large virtual screening to support hit discovery. As of the mid-2020s, leadXpro continues to operate as a private Swiss CRO, marketing itself on Swiss quality, collaboration and scientific excellence, and offering free feasibility assessments to new clients.

• 2015

  leadXpro founded in Switzerland as a Contract Research Organization focused on membrane proteins.

• Established protein science, biophysics and structures for 120 drug targets.

• Collaborated on 150+ projects on 120 different membrane proteins with leading biotech and pharmaceutical companies.

Swiss-quality contract research partner for structure-based drug discovery on challenging membrane protein targets, offering integrated protein science, biophysics and structural biology services.

• Gene-to-protein services

  Custom protein production from gene constructs, including construct design, expression and purification.

• Off-the-shelf proteins

  A catalog of 90+ ready-to-use proteins, list available upon request.

• Construct engineering and optimization

  Design and optimization of protein constructs for improved stability and function.

• Biophysical characterization

  Characterization and quantification of compounds for target engagement, affinity, kinetics, competition, allosteric modulation and thermodynamics using GCI, MST/TRIC and MS.

• Thermal stability assays

  Protein thermal stability and thermal shift assays using DSF, nanoDSF, CPM and FSEC-TS.

• Molecular and particle sizing

  Oligomerization and aggregation analysis using DLS and SLS.

• Nanobody/antibody binding characterization

  Binding characterization using GCI and analytical SEC.

• CryoEM structure determination

  Structural biology service using cryo-electron microscopy.

• Time-resolved X-ray crystallography

  Structural biology service for time-resolved crystallography.

• Ultra-large virtual screening

  Computational hit discovery service.

1. 1leadXpro – Unlocking membrane proteins for drug discoveryleadxpro.com
2. 2About us – leadXproleadxpro.com
3. 3Services – leadXproleadxpro.com
4. 4leadXpro – Wikidatawikidata.org