Conflex Corporation

Conflex Corporation is a Japanese computational chemistry software company headquartered in Minato-ku, Tokyo. Established in April 2000 with capital stock of ¥10,000,000, the company develops and licenses molecular modeling software, most notably the CONFLEX suite for conformation search and analysis. Its products help researchers explore the conformational space of small and large molecules, aiding in the selection of better quality leads during drug discovery. The company also develops the CONFLEX Interface, a visualization and analysis platform designed for analyzing CONFLEX outputs such as conformational analyses, spectra, and crystal packing. In addition to its own products, Conflex Corporation acts as a sales agent for third-party computational chemistry software including Gaussian, GaussView, TCPLinda, AMBER, and ChemDraw. The company provides computational chemistry services, contract computing, consulting, and training. It operates a USA office, CONFLEX USA, located in Carlsbad, California. The company is led by President & CEO Kazuo Ohta, with Motoharu Ohta as a board member and Hitoshi Goto as an outside director. Conflex Corporation continues to release updated versions of its software, with recent releases such as CONFLEX10, CONFLEX DOCK 1, and CONFLEX Interface10 in September 2025.

Conflex Corporation was established in April 2000 in Japan with capital stock of ¥10,000,000. The company was founded to provide computational chemistry solutions, focusing on conformation search and analysis software. In its founding year, it began parallelization of CONFLEX and became an official agent for AMBER. In 2001, the company released CONFLEX2000, a system for conformer creation, and Parallel CONFLEX. In 2002, it released BARISTA, a multi-conformation analysis system. In 2003, Conflex Corporation became a sales agent for Gaussian, Inc., offering Gaussian, GaussView, and TCPLinda. That same year, CONFLEX USA was established, and the company developed CONFLEX.NET, a system for providing molecular structures, with a grant from the Ministry of Internal Affairs and Communications for new projects in telecommunications and broadcasting. The head office was moved from Yokohama City, Kanagawa Prefecture, to Shinjuku-ku, Tokyo. In 2004, CONFLEX5 was released, followed by CONFLEX.NET in 2005 and CONFLEX6 in 2006. The head office was relocated from Shinjuku-ku to Shinagawa-ku, Tokyo, in 2006. Subsequent releases included CONFLEX6.2 in 2007, CONFLEX6.7 in 2009, and CONFLEX6.8 in 2011. In 2012, the company became a sales agent for PerkinElmer Informatics and released CONFLEX7.A. CONFLEX7.B followed in 2014, and CONFLEX7.C in 2015. In 2016, the head office moved from Shinagawa-ku to Minato-ku, Tokyo, and CONFLEX7.D was released. CONFLEX8.A was released in 2017. In 2018, the company's research division was designated as a research institute. The company has continued to develop its software, with recent releases in September 2025 including CONFLEX10 Rev.A, CONFLEX DOCK 1 Rev.A, and CONFLEX Interface10 Rev.A. Throughout its history, Conflex Corporation has expanded its product line and maintained a presence in both Japan and the United States, serving the computational chemistry community.

• 2025

  Release of CONFLEX10 Rev.A, CONFLEX DOCK 1 Rev.A, and CONFLEX Interface10 Rev.A in September.

• 2018

  Research division designated as a research institute.

• 2017

  Release of CONFLEX8.A.

• 2016

  Head office moved from Shinagawa-ku to Minato-ku, Tokyo. Release of CONFLEX7.D.

• 2015

  Release of CONFLEX7.C.

• 2014

  Release of CONFLEX7.B.

• 2012

  Sales agents of PerkinElmer Informatics. Release of CONFLEX7.A.

• 2011

  Release of CONFLEX6.8.

• 2009

  Release of CONFLEX6.7.

• 2007

  Release of CONFLEX6.2.

• 2006

  Release of CONFLEX6. Head office relocated from Shinjuku-ku to Shinagawa-ku, Tokyo.

• 2005

  Release of CONFLEX.NET.

• 2004

  Release of CONFLEX5.

• 2003

  Sales agents of Gaussian, Inc. (Gaussian, GaussView, TCPLinda). CONFLEX USA established. Development of CONFLEX.NET with grant from Ministry of Internal Affairs and Communications. Head office moved from Yokohama to Shinjuku-ku, Tokyo.

• 2002

  Multi-conformation analysis system BARISTA released.

• 2001

  Release of CONFLEX2000, a system for conformers creation. Release of Parallel CONFLEX.

• 2000

  Established CONFLEX Corporation. Start parallelization of CONFLEX. Official agents of AMBER.

High-accuracy computational chemistry software designed for chemists by chemists, serving both expert computational chemists and experimental/medicinal chemists.

• CONFLEX

  Conformation generation program that optimizes multiple starting structures generated by rotation of bonds and ring conformations, exploring the conformational space of flexible molecules.

• CONFLEX Interface

  Graphical user interface for submitting CONFLEX calculations and analyzing results, including conformational analyses, spectra output, and crystal packing.

• CONFLEX DOCK

  Molecular docking software, with version 1 Rev.A released in September 2025.

• CONFLEX.NET

  System for providing molecular structures, developed with a grant from the Ministry of Internal Affairs and Communications.

• BARISTA

  Multi-conformation analysis system released in 2002.

1. 1CONFLEX Corporationconflex.net
2. 2Products Overviewconflex.net
3. 3About CONFLEX Corporationconflex.net
4. 4Conflex Corporation (Japan) - Wikidatawikidata.org