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City Therapeutics, Inc.

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City Therapeutics is an RNAi therapeutics company founded by pioneers of RNAi to lead the next generation of RNAi-based medicines.

Last updated September 16, 2026

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Overview

City Therapeutics™ was founded by the pioneers of RNAi with a clear vision: to lead the next generation of RNAi therapeutics. Its approach is built on four principles: differentiated science, a strategic and diversified R&D pipeline, sustained momentum and unrivaled RNAi expertise. The company engineers trigger molecules with potency, specificity and durability, and pairs them with precision targeting ligands that deliver siRNAs to a broader range of cell and tissue types, expanding RNAi's reach beyond the liver.

History

City Therapeutics™ was founded by the pioneers of RNAi with a clear vision: to lead the next generation of RNAi therapeutics. The company states that its leaders helped build and shape the RNAi field and bring deep experience across research, development and regulatory strategy, and that this expertise extends throughout the organization, where scientists with decades of hands-on RNAi experience drive its programs forward.

Products and positioning

Leading the next generation of RNAi therapeutics; uniquely positioned to lead the next wave of RNAi breakthroughs with a differentiated siRNA engineering platform.

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