Biozeron Shenzhen, Inc.

Biozeron Shenzhen, Inc. is the Shenzhen-based arm of Shanghai Biozeron Biotechnology Co., Ltd. (凌恩生物), a Chinese high-technology company founded in late 2014 that provides research and technical services in the life sciences. The group focuses on the application of second-generation (short-read) and third-generation (single-molecule/long-read) high-throughput sequencing technologies to scientific research, agricultural development and human health. Its Shenzhen entity was established in 2018 specifically to serve large and complex genome projects. The company operates a broad multi-omics service portfolio. On the sequencing side it offers microbial diversity sequencing, full-length 16S/18S amplicon sequencing, metagenomics (including third-generation metagenomics and binning analysis), metatranscriptomics, environmental and medical viral metagenomics, plant and animal de novo genome sequencing, bacterial/fungal/viral genome sequencing, reduced-representation genome sequencing, GWAS, BSA bulked-segregant sequencing, genome resequencing, eQTL, eukaryotic and prokaryotic transcriptomics, full-length transcriptomics, lncRNA and small RNA sequencing, single-cell and single-nucleus transcriptomics, spatial transcriptomics, ATAC-seq, ChIP-seq, RIP-seq and whole-genome methylation analysis. It also provides targeted and untargeted metabolomics, proteomics (Astral), high-throughput soil biological testing, high-throughput 16S rDNA strain identification, mGWAS, database development and construction services, and customized bioinformatics analysis servers. Biozeron has built a complete omics data production line spanning second- and third-generation sequencing. It has introduced platforms including BGI's DNBSEQ-T7, DNBSEQ-G99 and DNBSEQ-E25, the DNBelab C4-TaiM4 single-cell platform, and BGI's Wutong nanopore sequencer, alongside its existing PacBio third-generation single-molecule sequencing platform. The company states that its services reach customers in multiple countries and regions worldwide, with cumulative service to tens of thousands of clients. Quality and recognition milestones include ISO quality management system certification in 2015, Shanghai High-Tech Enterprise certification in 2017, and inclusion on Shanghai's list of specialized, refined, distinctive and innovative (专精特新) enterprises in 2021. In 2018 the company partnered with the University of Illinois, the HudsonAlpha Institute for Biotechnology and NRGene to build a large-scale complex plant and animal genome research service platform, and established Biozeron Shenzhen, Inc. to handle large complex genome projects. It also formed a plant phenomics joint research center with Israel's PDT company. By the time of its public statements the company reported 58 patents and software copyrights and dozens of newly developed technology service types. Biozeron is positioned as a domestic Chinese provider of cutting-edge omics research services, filling gaps in technical service offerings for Chinese scientists. Notable technology introductions include the HiC-Meta three-dimensional metagenomics project (developed with Phase Genomics) launched in spring 2019, and early domestic adoption of environmental eDNA metabarcoding sequencing in late 2019. The company also operates cloud platforms, a pet microbiome testing service, and delivery/analysis platforms for customers.

Shanghai Biozeron Biotechnology Co., Ltd. (凌恩生物) was founded in late 2014 as a high-technology company engaged in biological science research technical services. From the outset it focused on applying second-generation high-throughput sequencing and third-generation single-molecule sequencing to scientific research, agricultural development and human health. In 2015 the company passed ISO quality management system certification. In 2017 it was awarded the Shanghai High-Tech Enterprise certificate. In 2018 Biozeron partnered with the University of Illinois, the HudsonAlpha Institute for Biotechnology and NRGene to jointly build a large-scale complex plant and animal genome research service platform, and established Biozeron Shenzhen, Inc. (凌恩生物科技（深圳）有限公司) specifically to handle large complex genome projects. In the same year it formed a plant phenomics joint research center with Israel's PDT company. Between 2019 and 2021 the company obtained multiple grade certificates including AAA-level quality service and integrity unit. In spring 2019 Biozeron presented HiC-Meta, described as China's first three-dimensional genomic meta-omics research project, at an exhibition. The technology combined Phase Genomics' three-dimensional genomics technology to overcome genome sequencing and assembly difficulties in complex samples, raising the assembly quality of single bacterial genomes from complex samples and enabling exploration of species interactions in environmental and medical research. At the end of 2019 the company took the lead domestically in carrying out environmental eDNA metabarcoding sequencing. In 2021 Biozeron was listed among Shanghai's specialized, refined, distinctive and innovative (专精特新) enterprises. Over the years the company introduced platforms including BGI's DNBSEQ-T7, DNBSEQ-G99 and DNBSEQ-E25 second-generation sequencers, the DNBelab C4-TaiM4 single-cell platform, and BGI's Wutong nanopore sequencer, combining these with its existing PacBio third-generation single-molecule sequencing platform to build a complete omics data production line covering second- and third-generation sequencing. It also added the 10x Chromium iX single-cell platform and the SURFseq Q series platform. By its own account the company had obtained 58 patents and software copyrights and developed dozens of new technology service types, serving customers in multiple countries and regions with cumulative service to tens of thousands of clients.

• 2021

  Listed among Shanghai's specialized, refined, distinctive and innovative (专精特新) enterprises.

• 2019

  Launched HiC-Meta, described as China's first three-dimensional genomic meta-omics research project, at an exhibition.

• 2019

  Took the lead domestically in carrying out environmental eDNA metabarcoding sequencing.

• 2018

  Partnered with University of Illinois, HudsonAlpha Institute for Biotechnology and NRGene to build a large complex plant and animal genome research service platform; established Biozeron Shenzhen, Inc.

• 2018

  Formed a plant phenomics joint research center with Israel's PDT company.

• 2017

  Awarded Shanghai High-Tech Enterprise certificate.

• 2015

  Passed ISO quality management system certification.

• 2014

  Shanghai Biozeron Biotechnology Co., Ltd. founded in late 2014.

Domestic Chinese provider of cutting-edge multi-omics research services, emphasizing second- and third-generation sequencing technology and filling gaps in technical service offerings for Chinese scientists.

• HiC-Meta three-dimensional metagenomics

  China's first three-dimensional genomic meta-omics research project, combining Phase Genomics' 3D genomics technology to improve single bacterial genome assembly from complex samples and explore species interactions.

• Environmental eDNA metabarcoding sequencing

  Among the first domestically to offer environmental eDNA metabarcoding sequencing.

• Third-generation metagenomics

  Long-read metagenomics with binning analysis and cMAGs complete-genome concepts.

• Single-cell transcriptomics multi-platform service

  Single-cell and single-nucleus transcriptomics using DNBelab C4-TaiM4, 10x Chromium iX and other platforms.

1. 1上海凌恩生物科技有限公司biozeron.com
2. 2上海凌恩生物科技有限公司biozeron.com
3. 3Biozeron Shenzhen, Inc. (China)wikidata.org