Lisinopril/hydrochlorothiazide, sold under the brand name Zestoretic among others, is a fixed-dose combination medication used for the treatment of high blood pressure (hypertension).[2] It contains lisinopril, an ACE inhibitor, and hydrochlorothiazide, a diuretic.[2] Typically, it becomes an option once a person is doing well on the individual components. It is taken by mouth.
Common side effects include dizziness, headache, cough, and feeling tired.[2] Severe side effects may include angioedema and low blood pressure.[2] Use during pregnancy may harm the baby.[2]
The combination was approved for medical use in the United States in 1989.