KQFX-LD (channel 22), branded Fox 22, is a low-power television station licensed to Columbia, Missouri, United States, serving as the Fox affiliate for the Columbia–Jefferson City market. It is owned by the News-Press & Gazette Company (NPG) alongside dual ABC/MyNetworkTV affiliate KMIZ (channel 17, also licensed to Columbia); the stations together are branded as the "Networks of Mid-Missouri". The two stations share studios on the East Business Loop 70 in Columbia; KQFX-LD's transmitter is located west of Jamestown near the Moniteau–Cooper county line.
In addition to its own digital signal, KQFX-LD is simulcast in high definition on KMIZ's fourth digital subchannel (17.4) from the same transmitter site.
KQFX-LD is the successor to three different low-power TV stations, two in Columbia and one in Jefferson City, the oldest of which began broadcasting in 1990. Benedek Broadcasting brought the Fox network to Mid-Missouri in 1997 by acquiring two of them and running them alongside KMIZ. The third was acquired in 2003 and is the current license on which the station has operated since the digital television transition in 2009. KQFX offers morning and late newscasts produced by KMIZ.